Chromosome 17 | Cancer Genetics Web

Genes Linked with Cancer (125)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 17; or Sort by clicking on a column heading e.g. 'Gene'.

Gene	Location	Aliases	Abnormalities	Implicated in
SPECC1	17p11.2	NSP, CYTSB, HCMOGT1, HCMOGT-1	Somatic	-Head and Neck Cancers
ALDH3A1	17p11.2	ALDH3, ALDHIII		-Breast Cancer -Cervical Cancer -Lung Cancer
SHMT1	17p11.2	SHMT, CSHMT		-Acute Lymphocytic Leukaemia (ALL) -Bladder Cancer -Breast Cancer -Lung Cancer -Non-Hodgkin Lymphoma -Prostate Cancer -Stomach Cancer
FLCN	17p11.2	BHD, FLCL	Germline	-Breast Cancer -Kidney Cancer -Prostate Cancer -Skin Cancer -Uterine Sarcoma
SREBF1	17p11.2	SREBP1, bHLHd1, SREBP1a, SREBP-1c		-Breast Cancer -Liver Cancer -Prostate Cancer
MAP2K4	17p12	JNKK, MEK4, MKK4, SEK1, SKK1, JNKK1, SERK1, MAPKK4, PRKMK4, SAPKK1, SAPKK-1	Somatic	-Bladder Cancer -Breast Cancer -Lung Cancer -Ovarian Cancer -Pancreatic Cancer -Prostate Cancer -Soft Tissue Sarcoma -Stomach Cancer
ELAC2	17p12	ELC2, HPC2, COXPD17		-Prostate Cancer
NCOR1	17p12-p11.2	N-CoR, TRAC1, N-CoR1, hN-CoR, PPP1R109		-Breast Cancer -Prostate Cancer
PMP22	17p12	DSS, CIDP, GAS3, HNPP, CMT1A, CMT1E, GAS-3, Sp110, HMSNIA		-Bone Cancer (primary) -Brain Tumours, Childhood -Breast Cancer -Osteosarcoma
SAT2	17p13.1	SSAT2		-Breast Cancer -Colorectal Cancer -Liver Cancer -Ovarian Cancer -Prostate Cancer -Stomach Cancer
KDM6B	17p13.1	JMJD3		-Prostate Cancer
XAF1	17p13.1	BIRC4BP, XIAPAF1, HSXIAPAF1		-Bladder Cancer -Colorectal Cancer -Liver Cancer -Lung Cancer -Prostate Cancer -Stomach Cancer
RCVRN	17p13.1	RCV1		-Bladder Cancer -Eye Cancer -Lung Cancer -Small Cell Lung Cancer -Retinoblastoma
CD68	17p13.1	GP110, LAMP4, SCARD1		-Brain Tumours, Childhood -Breast Cancer -Hodgkin Lymphoma -Lung Cancer -Melanoma -Pancreatic Cancer -Skin Cancer
TNFSF13	17p13.1	APRIL, CD256, TALL2, ZTNF2, TALL-2, TNLG7B, TRDL-1, UNQ383/PRO715		-Cervical Cancer -Chronic Lymphocytic Leukemia -Colorectal Cancer -Lung Cancer -Multiple Myeloma
TP53	17p13.1	P53, BCC7, LFS1, TRP53	Germline & Somatic	Many cancer types including: -Li-Fraumeni syndrome -MALT Lymphoma -Adrenocortical Cancer -Bladder Cancer -Brain Tumours, Childhood -Breast Cancer -Childhood Leukaemia -Chronic Lymphocytic Leukemia -Colorectal Cancer -Endometrial Cancer -Esophageal Cancer -Ewing's Sarcoma -Fallopian tube cancer -Hairy Cell Leukemia -Laryngeal Cancer -Leukaemia -Liver Cancer -Lung Cancer -Lung Cancer, Non-Small Cell -Mantle-Cell Lymphoma -Medulloblastoma -Melanoma -Mesothelioma -Neuroblastoma -Osteosarcoma -Ovarian Cancer -Pancreatic Cancer -Prostate Cancer -Rhabdomyosarcoma
GAS7	17p13.1		Somatic	-Breast Cancer -Colorectal Cancer -Leukaemia -Lung Cancer -Neuroblastoma -Osteosarcoma
CLDN7	17p13.1	CLDN-7, CEPTRL2, CPETRL2, Hs.84359, claudin-1		-Breast Cancer -Colorectal Cancer -Lung Cancer -Pancreatic Cancer -Stomach Cancer
SHBG	17p13.1	ABP, SBP, TEBG		-Breast Cancer -Cervical Cancer -Prostate Cancer
EFNB3	17p13.1	EFL6, EPLG8, LERK8		-Neuroblastoma
AURKB	17p13.1	AIK2, AIM1, ARK2, AurB, IPL1, STK5, AIM-1, STK12, PPP1R48, aurkb-sv1, aurkb-sv2		-Cervical Cancer -Small Cell Lung Cancer -Thyroid Cancer
PER1	17p13.1	PER, hPER, RIGUI	Somatic	-Breast Cancer -Cervical Cancer -Colorectal Cancer -Liver Cancer -Prostate Cancer -Stomach Cancer
RABEP1	17p13.2	RAB5EP, RABPT5	Somatic	-Breast Cancer -Prostate Cancer -Stomach Cancer
ALOX15	17p13.2	12-LOX, 15LOX-1, 15-LOX-1		-Colorectal Cancer -Prostate Cancer
USP6	17p13.2	HRP1, TRE2, TRE17, Tre-2, TRESMCR, USP6-short	Somatic	-Bone Cancer (primary) -Breast Cancer -Uterine Sarcoma
CXCL16	17p13.2	SRPSOX, CXCLG16, SR-PSOX		-Bone Cancer (primary) -Breast Cancer -Liver Cancer -Pancreatic Cancer -Prostate Cancer -Rectal Cancer -Stomach Cancer
PELP1	17p13.2	MNAR, P160		-Breast Cancer -Ovarian Cancer
YWHAE	17p13.3	MDS, HEL2, MDCR, KCIP-1, 14-3-3E	Somatic	-Endometrial Cancer -Kidney Cancer -Liver Cancer -Stomach Cancer -Uterine Sarcoma
HIC1	17p13.3	hic-1, ZBTB29, ZNF901		-Breast Cancer -Cervical Cancer -Colorectal Cancer -Medulloblastoma -Stomach Cancer
CRK	17p13.3	p38, CRKII		-Breast Cancer -Lung Cancer -Lung Cancer, Non-Small Cell
DPH1	17p13.3	DPH2L, OVCA1, DEDSSH, DPH2L1		-Acute Lymphocytic Leukaemia (ALL) -Ovarian Cancer
RPA1	17p13.3	HSSB, RF-A, RP-A, REPA1, RPA70, MST075		-Breast Cancer -Lung Cancer -Skin Cancer
PIGS	17q11.2			-Breast Cancer -Liver Cancer -Melanoma -Pancreatic Cancer -Thyroid Cancer
NOS2	17q11.2	NOS, INOS, NOS2A, HEP-NOS		-Bladder Cancer -Breast Cancer -Colorectal Cancer -Stomach Cancer
NF1	17q11.2	WSS, NFNS, VRNF	Germline & Somatic	-Adrenocortical Cancer -Brain Tumours, Childhood -Pheochromocytoma and Paraganglioma -Skin Cancer -Uterine Sarcoma
SUZ12	17q11.2	CHET9, JJAZ1	Somatic	-Breast Cancer -Endometrial Cancer -Prostate Cancer -Stomach Cancer
CCL4	17q12	ACT2, G-26, HC21, LAG1, LAG-1, MIP1B, SCYA2, SCYA4, MIP1B1, AT744.1, MIP-1-beta		-Chronic Lymphocytic Leukemia -Liver Cancer -Multiple Myeloma
LASP1	17q12	MLN50, Lasp-1	Somatic	-Bladder Cancer -Breast Cancer -Colorectal Cancer -Prostate Cancer
PCGF2	17q12	MEL-18, RNF110, ZNF144		-Breast Cancer -Prostate Cancer
CCL5	17q12	SISd, eoCP, SCYA5, RANTES, TCP228, D17S136E, SIS-delta		-Breast Cancer -Ovarian Cancer -Stomach Cancer -Thyroid Cancer
CCL3	17q12	MIP1A, SCYA3, G0S19-1, LD78ALPHA, MIP-1-alpha		-Breast Cancer -Chronic Lymphocytic Leukemia -Lung Cancer -Multiple Myeloma
TAF15	17q12	Npl3, RBP56, TAF2N, TAFII68	Somatic Translocation	-Acute Lymphocytic Leukaemia (ALL) -Bone Cancer (primary) -Chondrosarcoma -Ewing's Sarcoma -Soft Tissue Sarcoma
CCL2	17q12	HC11, MCAF, MCP1, MCP-1, SCYA2, GDCF-2, SMC-CF, HSMCR30		-Breast Cancer -Cervical Cancer -Liver Cancer -Lung Cancer -Prostate Cancer -Stomach Cancer
MED1	17q12	PBP, CRSP1, RB18A, TRIP2, PPARBP, CRSP200, DRIP205, DRIP230, PPARGBP, TRAP220		-Breast Cancer -Colorectal Cancer -Lung Cancer -Prostate Cancer
MLLT6	17q12	AF17	Somatic	-Acute Lymphocytic Leukaemia (ALL) -Acute Myeloid Leukaemia -Leukaemia
CDK12	17q12	CRK7, CRKR, CRKRS	Somatic	-Breast Cancer -Neuroblastoma -Ovarian Cancer -Stomach Cancer
RAD51D	17q12	TRAD, R51H3, BROVCA4, RAD51L3		-Breast Cancer -Hereditary Breast and Ovarian Cancer Syndrome -Ovarian Cancer
GRB7	17q12			-Breast Cancer -Stomach Cancer
ERBB2	17q12	NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu	Somatic Gene Amplification	-Bladder Cancer -Breast Cancer -Fallopian tube cancer -Lung Cancer -Medulloblastoma -Osteosarcoma -Ovarian Cancer -Prostate Cancer -Uterine Sarcoma
HNF1B	17q12	FJHN, HNF2, LFB3, TCF2, HPC11, LF-B3, MODY5, TCF-2, VHNF1, HNF-1B, HNF1beta, HNF-1-beta		-Kidney Cancer -Liver Cancer -Ovarian Cancer -Prostate Cancer
THRA	17q21.1	AR7, EAR7, ERBA, CHNG6, ERBA1, NR1A1, THRA1, THRA2, ERB-T-1, c-ERBA-1		-Breast Cancer -Multiple Myeloma -Thyroid Cancer
TOP2A	17q21.2	TOP2, TP2A		-Breast Cancer -Colorectal Cancer -Esophageal Cancer -Lung Cancer -Soft Tissue Sarcoma -Stomach Cancer
STAT5B	17q21.2	STAT5		-Breast Cancer
HSD17B1	17q21.2	E2DH, HSD17, EDHB17, EDH17B2, SDR28C1, 17-beta-HSD, 20-alpha-HSD		-Breast Cancer -Colorectal Cancer -Endometrial Cancer -Prostate Cancer -Stomach Cancer
RARA	17q21.2	RAR, NR1B1	Somatic Translocation	-Acute Myeloid Leukaemia -Childhood Cancers -Leukaemia
CCR7	17q21.2	BLR2, EBI1, CCR-7, CD197, CDw197, CMKBR7, CC-CKR-7		-Breast Cancer -Chronic Lymphocytic Leukemia -Eye Cancer -Head and Neck Cancers -Liver Cancer -Lung Cancer -Melanoma -Skin Cancer
CDC6	17q21.2	CDC18L, HsCDC6, MGORS5, HsCDC18		-Breast Cancer -Cervical Cancer -Liver Cancer -Lung Cancer -Prostate Cancer
KRT20	17q21.2	K20, CD20, CK20, CK-20, KRT21		-Bladder Cancer -Colorectal Cancer -Skin Cancer -Stomach Cancer -Thyroid Cancer
STAT3	17q21.2	APRF, HIES, ADMIO, ADMIO1		-Bladder Cancer -Breast Cancer -Colorectal Cancer -Liver Cancer -Lung Cancer -Lung Cancer, Non-Small Cell -Osteosarcoma
STAT5A	17q21.2	MGF, STAT5		-Breast Cancer -Chronic Myelogenous Leukemia -Prostate Cancer -Skin Cancer
IGFBP4	17q21.2	BP-4, IBP4, IGFBP-4, HT29-IGFBP		-Breast Cancer -Lung Cancer -Small Cell Lung Cancer
KRT14	17q21.2	K14, NFJ, CK14, EBS3, EBS4		-Bladder Cancer -Breast Cancer -Cervical Cancer -Salivary Gland Cancer -Skin Cancer -Urinary System Cancers
KRT19	17q21.2	K19, CK19, K1CS		-Breast Cancer -Kidney Cancer -Liver Cancer -Uterine Sarcoma
GAST	17q21.2	GAS		-Acute Lymphocytic Leukaemia (ALL) -Melanoma -Ovarian Cancer -Skin Cancer
ETV4	17q21.31	E1AF, PEA3, E1A-F, PEAS3	Somatic Translocation	-Ewing's Sarcoma -Prostate Cancer
BECN1	17q21.31	ATG6, VPS30, beclin1		-Breast Cancer -Cervical Cancer -Liver Cancer -Lung Cancer
WNT3	17q21.31-q21.32	INT4, TETAMS		-Breast Cancer -Liver Cancer
NBR1	17q21.31	IAI3B, M17S2, MIG19, 1A1-3B		-Breast Cancer -Ovarian Cancer
GFAP	17q21.31	ALXDRD		-Astrocytoma, Childhood -Brain and CNS Tumours -Brain Stem Glioma, Childhood -Brain Tumours, Childhood
BRCA1	17q21.31	IRIS, PSCP, BRCAI, BRCC1, FANCS, PNCA4, RNF53, BROVCA1, PPP1R53	Germline & Somatic	-Breast Cancer -Breast Cancer, Familial -Cancer Screening -Colorectal Cancer -Fallopian tube cancer -Hereditary Breast and Ovarian Cancer Syndrome -Ovarian Cancer -Prostate Cancer
HOXB13	17q21.32	PSGD	Germline & Somatic	-Prostate Cancer
TBX21	17q21.32	TBET, T-PET, T-bet, TBLYM		-Breast Cancer -Hodgkin Lymphoma -Lung Cancer -Paranasal Sinus and Nasal Cavity Cancer -Stomach Cancer
HOXB4	17q21.32	HOX2, HOX2F, HOX-2.6		-Acute Myeloid Leukaemia -Cervical Cancer -Leukaemia -Lung Cancer -Wilms Tumour
ITGB3	17q21.32	GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16		-Bladder Cancer -Breast Cancer -Colorectal Cancer -Lung Cancer -Lung Cancer, Non-Small Cell -Ovarian Cancer -Prostate Cancer -Stomach Cancer
MIR10A	17q21.32	MIRN10A, mir-10a, miRNA10A, hsa-mir-10a		-Acute Myeloid Leukaemia -Bladder Cancer -Brain Stem Glioma, Childhood -Brain Tumours, Childhood -Breast Cancer -Cervical Cancer -Pancreatic Cancer -Prostate Cancer -Rectal Cancer -Stomach Cancer
HOXB7	17q21.32	HOX2, HOX2C, HHO.C1, Hox-2.3		-Breast Cancer -Esophageal Cancer -Lung Cancer -Melanoma -Pancreatic Cancer
HOXB3	17q21.32	HOX2, HOX2G, Hox-2.7		-Acute Myeloid Leukaemia -Leukaemia -Lung Cancer -Stomach Cancer
CACNA1G	17q21.33	NBR13, SCA42, Cav3.1, Ca(V)T.1		-Colorectal Cancer -Eye Cancer -Retinoblastoma
DLX4	17q21.33	BP1, DLX7, DLX8, DLX9, OFC15		-Acute Myeloid Leukaemia -Breast Cancer -Cervical Cancer -Leukaemia -Lung Cancer -Lung Cancer, Non-Small Cell
ABCC3	17q21.33	MLP2, MRP3, ABC31, MOAT-D, cMOAT2, EST90757		-Breast Cancer -Childhood Cancers
NGFR	17q21.33	CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR		-Brain Tumours, Childhood -Breast Cancer -Medulloblastoma -Melanoma -Neuroblastoma -Prostate Cancer
NME2	17q21.33	PUF, NDKB, NDPKB, NM23B, NDPK-B, NM23-H2		-Breast Cancer -Neuroblastoma
NME1	17q21.33	NB, AWD, NBS, GAAD, NDKA, NM23, NDPKA, NDPK-A, NM23-H1		-Bladder Cancer -Breast Cancer -Cervical Cancer -Eye Cancer -Lung Cancer -Neuroblastoma -Uterine Sarcoma
COL1A1	17q21.33	OI1, OI2, OI3, OI4, EDSC	Somatic Translocation	-Breast Cancer -Skin Cancer -Dermatofibrosarcoma Protuberans -Soft Tissue Sarcoma -Stomach Cancer -Vulvar Cancer
BCL5	17q22		Somatic	-Leukaemia
HLF	17q22		Somatic Translocation	-Acute Lymphocytic Leukaemia (ALL) -Leukaemia -Liver Cancer
MSI2	17q22	MSI2H	Somatic	-Acute Myeloid Leukaemia -Bladder Cancer -Chronic Myelogenous Leukemia -Leukaemia -Stomach Cancer
RAD51C	17q22	FANCO, R51H3, BROVCA3, RAD51L2		-Breast Cancer -Fanconi Anaemia -Hereditary Breast and Ovarian Cancer Syndrome -Ovarian Cancer
COIL	17q22	CLN80, p80-coilin		-Breast Cancer -Uterine Sarcoma
MIR21	17q23.1	MIRN21, miR-21, miRNA21, hsa-mir-21		-Brain and CNS Tumours -Breast Cancer -Colorectal Cancer -Head and Neck Cancers -Liver Cancer -Lung Cancer -Squamous Cell Carcinoma - Skin
RPS6KB1	17q23.1	S6K, PS6K, S6K1, STK14A, p70-S6K, p70 S6KA, p70-alpha, S6K-beta-1, p70(S6K)-alpha		-Breast Cancer
CLTC	17q23.1	Hc, CHC, CHC17, CLH-17, CLTCL2	Somatic	-Kidney Cancer -Lung Cancer
PPM1D	17q23.2	WIP1, PP2C-DELTA		-Brain Stem Glioma, Childhood -Breast Cancer -Lung Cancer -Medulloblastoma -Ovarian Cancer
TBX2	17q23.2			-Bladder Cancer -Breast Cancer -Melanoma -Pancreatic Cancer
BRIP1	17q23.2	OF, BACH1, FANCJ	Germline	-Fanconi Anaemia
DDX5	17q23.3	p68, HLR1, G17P1, HUMP68	Somatic	-Breast Cancer -Colorectal Cancer -Prostate Cancer -Stomach Cancer
PECAM1	17q23.3	CD31, PECA1, GPIIA', PECAM-1, endoCAM, CD31/EndoCAM		-Acute Lymphocytic Leukaemia (ALL) -Brain Tumours, Childhood -Breast Cancer -Cervical Cancer -Haematological Malignancies -Kidney Cancer -Liver Cancer -Lung Cancer
STRADA	17q23.3	LYK5, PMSE, Stlk, STRAD, NY-BR-96		-Breast Cancer -Pancreatic Cancer -Prostate Cancer -Transitional Cell Cancer of the Renal Pelvis and Ureter
CD79B	17q23.3	B29, IGB, AGM6	Somatic	-Acute Lymphocytic Leukaemia (ALL) -Chronic Lymphocytic Leukemia -Hodgkin Lymphoma -Skin Cancer -Testicular Cancer
AXIN2	17q24.1	AXIL, ODCRCS		-Adenomatous Polyposis Coli -Colorectal Cancer -Liver Cancer -Ovarian Cancer -Thyroid Cancer
KPNA2	17q24.2	QIP2, RCH1, IPOA1, SRP1alpha, SRP1-alpha		-Breast Cancer -Esophageal Cancer -Lung Cancer -Prostate Cancer
PRKCA	17q24.2	AAG6, PKCA, PRKACA, PKC-alpha		-Breast Cancer -Lung Cancer -Skin Cancer -Stomach Cancer -Thyroid Cancer
PRKAR1A	17q24.2	CAR, CNC, CNC1, PKR1, TSE1, ADOHR, PPNAD1, PRKAR1, ACRDYS1	Germline & Somatic	-Multiple Endocrine Neoplasia -Pituitary Tumors -Skin Cancer -Thyroid Cancer
SOX9	17q24.3	CMD1, SRA1, CMPD1, SRXX2, SRXY10		-Colorectal Cancer -Pancreatic Cancer -Prostate Cancer -Stomach Cancer
MAP2K6	17q24.3	MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3, SAPKK-3		-Bladder Cancer -Breast Cancer -Colorectal Cancer -Stomach Cancer
SSTR2	17q25.1			-Breast Cancer -Lung Cancer -Medulloblastoma -Neuroblastoma -Pancreatic Cancer -Pituitary Tumors -Stomach Cancer
SLC9A3R1	17q25.1	EBP50, NHERF, NHERF1, NHERF-1, NPHLOP2		-Liver Cancer
GRB2	17q25.1	ASH, Grb3-3, MST084, NCKAP2, MSTP084, EGFRBP-GRB2		-Breast Cancer -Chronic Myelogenous Leukemia
RHBDF2	17q25.1	TEC, TOC, TOCG, RHBDL5, RHBDL6, iRhom2		-Esophageal Cancer -Ovarian Cancer
ITGB4	17q25.1	CD104, GP150		-Bladder Cancer -Breast Cancer -Oral Cavity Cancer -Pancreatic Cancer
SRSF2	17q25.1	SC35, PR264, SC-35, SFRS2, SFRS2A, SRp30b	Somatic	-Acute Myeloid Leukaemia -Cervical Cancer -Chronic Myelogenous Leukemia -Haematological Malignancies -Myelodysplastic Syndromes -Myeloproliferative Disorders
SPHK1	17q25.1	SPHK		-Breast Cancer -Colorectal Cancer -Liver Cancer -Stomach Cancer
RAC3	17q25.3			-Breast Cancer -Esophageal Cancer -Lung Cancer -Prostate Cancer
TIMP2	17q25.3	DDC8, CSC-21K		-Bladder Cancer -Breast Cancer -Cervical Cancer -Chondrosarcoma -Liver Cancer -Lung Cancer -Melanoma -Prostate Cancer
ASPSCR1	17q25.3	TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9, ASPCR1	Somatic Translocation	-Brain Tumours, Childhood -Kidney Cancer -Lung Cancer -Soft Tissue Sarcoma
ZNF750	17q25.3	ZFP750	Deletion	-Esophageal Cancer -Skin Cancer
FASN	17q25.3	FAS, OA-519, SDR27X1		-Breast Cancer -Colorectal Cancer -Liver Cancer -Ovarian Cancer -Prostate Cancer -Uterine Sarcoma
MAFG	17q25.3	hMAF		-Chronic Myelogenous Leukemia -Colorectal Cancer -Esophageal Cancer -Lung Cancer -Melanoma
CANT1	17q25.3	DBQD, DBQD1, SCAN1, SHAPY, SCAN-1	Somatic	-Melanoma -Prostate Cancer
BIRC5	17q25.3	API4, EPR-1		-Bladder Cancer -Breast Cancer -Lung Cancer -Small Cell Lung Cancer -Neuroblastoma -Skin Cancer -Thyroid Cancer -Wilms Tumour
SOCS3	17q25.3	CIS3, SSI3, ATOD4, Cish3, SSI-3, SOCS-3		-Breast Cancer -Liver Cancer -Lung Cancer -Lung Cancer, Non-Small Cell -Prostate Cancer
RNF213	17q25.3	ALO17, MYMY2, MYSTR, NET57, C17orf27, KIAA1618	Somatic	-Brain Stem Glioma, Childhood -Brain Tumours, Childhood -Head and Neck Cancers -Synovial Sarcoma
SEPT9	17q25.3	MSF, MSF1, NAPB, SINT1, PNUTL4, SeptD1, AF17q25	Somatic	-Acute Myeloid Leukaemia -Breast Cancer -Cancer Screening -Colorectal Cancer
TMC6	17q25.3	EV1, EVER1, EVIN1, LAK-4P		-Cervical Cancer -Head and Neck Cancers -Laryngeal Cancer -Oral Cavity Cancer -Skin Cancer
TMC8	17q25.3	EV2, EVER2, EVIN2		-Cervical Cancer -Head and Neck Cancers -Laryngeal Cancer -Oral Cavity Cancer -Skin Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 17:

Abnormality	Type	Gene(s)
Loss of 17p in Childhood CNS tumours	Deletion
Gain of Chromosome 17q in Neuroblastoma	Gain
Isochromosome 17q in Medulloblastoma	Isochromosome
LOH 17p in Colorectal Cancer	Loss
der(17)t(X;17) (p11.2;q25) in Alveolar Soft-Part Sarcoma	Translocation
t(17;22)(q22;q13) COL1A1-PDGFB in Dermatofibrosarcoma Protuberans	Translocation	COL1A1 (17q21.33)	PDGFB (22q13.1)
t(17;22)(q12;q12) EWSR1-E1AF Translocation in Ewing's Sarcoma	Translocation	ETV4 (17q21.31)	EWSR1 (22q12.2)
t(11;17) ALL1-MLLT6 in Acute Leukaemias	Translocation	MLLT6 (17q12)	KMT2A (11q23.3)
t(5;17)(q32;q11) RARA-NPM translocations in Acute Promyelocytic Leukemia	Translocation	RARA (17q21.2)	NPM1 (5q35.1)
t(11;17)(q32;q21) RARA-PLZF in Acute Promyelocytic Leukemia	Translocation	RARA (17q21.2)	ZBTB16 (11q23.2)
t(15;17)(q21;q21) RARA-PML translocation in Acute Promyelocytic Leukaemia	Translocation	RARA (17q21.2)	PML (15q24.1)
t(17;19)(q22;p13) TCF3-HLF fusion in Acute Lymphoblastic Leukemia	Translocation	HLF (17q22)	TCF3 (19p13.3)
der(17)t(X;17)(p11.2;q25) in Alveolar Soft-Part Sarcoma	Translocation	ASPSCR1 (17q25.3)	TFE3 (Xp11.23)
t(9;17)(q22;q11) in Extraskeletal Myxoid Chondrosarcoma	Translocation	TAF15 (17q12)	NR4A3 (9q31.1)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.