Chromosome 14 | Cancer Genetics Web

Genes Linked with Cancer (61)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 14; or Sort by clicking on a column heading e.g. 'Gene'.

Gene	Location	Aliases	Abnormalities	Implicated in
SCFV	14			-Breast Cancer -Multiple Myeloma -Neuroblastoma -Stomach Cancer
TRD	14q11.2	TCRD, TRD@, TCRDV1	Somatic	-Lung Cancer
BCL2L2	14q11.2	BCLW, BCL-W, PPP1R51, BCL2-L-2		-Bladder Cancer -Breast Cancer -Colorectal Cancer -Liver Cancer -Lung Cancer -Osteosarcoma
APEX1	14q11.2	APE, APX, APE1, APEN, APEX, HAP1, REF1		-Cervical Cancer -Skin Cancer -Stomach Cancer -Thyroid Cancer
CEBPE	14q11.2	CRP1, C/EBP-epsilon		-Acute Lymphocytic Leukaemia (ALL) -Acute Myeloid Leukaemia
NDRG2	14q11.2	SYLD		-Brain Tumours, Childhood -Breast Cancer -Cervical Cancer -Colorectal Cancer -Liver Cancer -Prostate Cancer -Skin Cancer
TEP1	14q11.2	TP1, TLP1, p240, TROVE1, VAULT2		-Bladder Cancer -Breast Cancer -Cervical Cancer
CCNB1IP1	14q11.2	HEI10, C14orf18	Somatic	-Brain Stem Glioma, Childhood -Brain Tumours, Childhood -Rectal Cancer
MMP14	14q11.2	MMP-14, MMP-X1, MT-MMP, MT1MMP, MTMMP1, WNCHRS, MT1-MMP, MT-MMP 1		-Bladder Cancer -Breast Cancer -Cervical Cancer -Lung Cancer -Stomach Cancer
TRA	14q11.2	IMD7, TCRA, TCRD, TRA@, TRAC	Somatic	-Breast Cancer -Chronic Myelogenous Leukemia -Colorectal Cancer -Lung Cancer -Uterine Sarcoma
FOXG1	14q12	BF1, BF2, QIN, FKH2, HBF2, HFK1, HFK2, HFK3, KHL2, FHKL3, FKHL1, FKHL2, FKHL3, FKHL4, HBF-1, HBF-2, HBF-3, FOXG1A, FOXG1B, FOXG1C, HBF-G2		-Brain Tumours, Childhood -Cervical Cancer -Prostate Cancer -Wilms Tumour
IRF9	14q12	p48, IRF-9, ISGF3, ISGF3G		-Bladder Cancer -Liver Cancer -Melanoma -Skin Cancer
GZMB	14q12	C11, HLP, CCPI, CGL1, CSPB, SECT, CGL-1, CSP-B, CTLA1, CTSGL1		-Breast Cancer -Cervical Cancer -Colorectal Cancer -Waldenstrom's Macroglobulinemia
EGLN3	14q13.1	PHD3, HIFPH3, HIFP4H3		-Adrenocortical Cancer -Breast Cancer -Kidney Cancer -Pheochromocytoma and Paraganglioma -von Hippel-Lindau Disease -Waldenstrom's Macroglobulinemia
NFKBIA	14q13.2	IKBA, MAD-3, NFKBI		-Brain Tumours, Childhood -Breast Cancer -Colorectal Cancer -Hodgkin Lymphoma -Liver Cancer -Lung Cancer -Prostate Cancer -Stomach Cancer -Thyroid Cancer
NKX2-1	14q13.3	BCH, BHC, NK-2, TEBP, TTF1, NKX2A, NMTC1, T/EBP, TITF1, TTF-1, NKX2.1	Somatic	-Lung Cancer -Lung Cancer, Non-Small Cell -Thyroid Cancer
SSTR1	14q21.1	SS1R, SS1-R, SRIF-2, SS-1-R		-Breast Cancer -Carcinoid Tumours -Lung Cancer -Neuroblastoma -Pancreatic Cancer -Pituitary Tumors -Prostate Cancer -Soft Tissue Sarcoma -Stomach Cancer -Thyroid Cancer
FOXA1	14q21.1	HNF3A, TCF3A		-Breast Cancer -Prostate Cancer
PNN	14q21.1	DRS, DRSP, SDK3, memA		-Acute Lymphocytic Leukaemia (ALL) -Acute Myeloid Leukaemia -Bladder Cancer -Breast Cancer -Carcinoid Tumours -Colorectal Cancer -Leukaemia -Lung Cancer -Small Cell Lung Cancer -Melanoma -Neuroblastoma -Rhabdomyosarcoma -Skin Cancer
FANCM	14q21.2	FAAP250, KIAA1596	Germline	-Fanconi Anaemia
NEMF	14q21.3	NY-CO-1, SDCCAG1		-Colorectal Cancer -Esophageal Cancer -Lung Cancer -Lung Cancer, Non-Small Cell
PTGER2	14q22.1	EP2		-Colorectal Cancer -Lung Cancer -Lung Cancer, Non-Small Cell
NIN	14q22.1	SCKL7	Somatic	-Stomach Cancer
BMP4	14q22.2	ZYME, BMP2B, OFC11, BMP2B1, MCOPS6		-Breast Cancer -Colorectal Cancer -Ovarian Cancer -Skin Cancer
KTN1	14q22.3	CG1, KNT, MU-RMS-40.19	Somatic	-Bone Cancer (primary) -Liver Cancer -Thyroid Cancer
LGALS3	14q22.3	L31, GAL3, MAC2, CBP35, GALBP, GALIG, LGALS2		-Bladder Cancer -Breast Cancer -Cervical Cancer -Kidney Cancer -Pheochromocytoma and Paraganglioma -Stomach Cancer
OTX2	14q22.3	CPHD6, MCOPS5		-Brain Tumours, Childhood -Medulloblastoma -Retinoblastoma
SIX1	14q23.1	BOS3, TIP39, DFNA23		-Breast Cancer -Cervical Cancer -Wilms Tumour
ARID4A	14q23.1	RBP1, RBBP1, RBP-1, RBBP-1		-Breast Cancer
HIF1A	14q23.2	HIF1, MOP1, PASD8, HIF-1A, bHLHe78, HIF-1alpha, HIF1-ALPHA, HIF-1-alpha		-Bladder Cancer -Breast Cancer -Cervical Cancer -Kidney Cancer -Liver Cancer -Lung Cancer -Small Cell Lung Cancer -Pancreatic Cancer -Pheochromocytoma and Paraganglioma -Prostate Cancer -Stomach Cancer -Thyroid Cancer -Urinary System Cancers -von Hippel-Lindau Disease
ESR2	14q23.2-q23.3	Erb, ESRB, ESTRB, NR3A2, ER-BETA, ESR-BETA		-Breast Cancer -Colorectal Cancer -Endometrial Cancer -Lung Cancer -Ovarian Cancer -Prostate Cancer -Uterine Sarcoma
MTHFD1	14q23.3	MTHFC, MTHFD		-Acute Lymphocytic Leukaemia (ALL) -Breast Cancer -Cervical Cancer -Colorectal Cancer -Head and Neck Cancers -Ovarian Cancer
MAX	14q23.3	bHLHd4		-Adrenocortical Cancer -Breast Cancer -Colorectal Cancer -Lung Cancer -Lung Cancer, Non-Small Cell -Neuroblastoma -Pheochromocytoma and Paraganglioma
GPHN	14q23.3-q24.1	GPH, GEPH, HKPX1, GPHRYN, MOCODC	Somatic	-Lung Cancer -Prostate Cancer
GPX2	14q23.3	GPRP, GPx-2, GI-GPx, GPRP-2, GPx-GI, GSHPx-2, GSHPX-GI		-Breast Cancer -Colorectal Cancer -Esophageal Cancer -Lung Cancer -Prostate Cancer -Wilms Tumour
RAD51B	14q24.1	REC2, R51H2, RAD51L1	Somatic	-Breast Cancer -Uterine Sarcoma
NUMB	14q24.2-q24.3	S171, C14orf41, c14_5527		-Bladder Cancer -Brain Stem Glioma, Childhood -Breast Cancer -Cervical Cancer -Lung Cancer -Lung Cancer, Non-Small Cell
TGFB3	14q24.3	ARVD, LDS5, RNHF, ARVD1, TGF-beta3		-Breast Cancer -Cervical Cancer -Lung Cancer -Prostate Cancer -Uterine Sarcoma
FOS	14q24.3	p55, AP-1, C-FOS		-Breast Cancer -Colorectal Cancer -Liver Cancer -Lung Cancer -Osteosarcoma -Prostate Cancer -Rhabdomyosarcoma -Salivary Gland Cancer -Skin Cancer -Stomach Cancer
MLH3	14q24.3	HNPCC7		-Colorectal Cancer -Hereditary Nonpolyposis Colorectal Cancer (HNPCC) -Ovarian Cancer -Stomach Cancer
TSHR	14q31.1	LGR3, CHNG1, hTSHR-I	Germline & Somatic
FOXN3	14q31.3-q32.11	CHES1, PRO1635, C14orf116		-Pancreatic Cancer
TRIP11	14q32.12	ACG1A, CEV14, GMAP210, TRIP-11, TRIP230, GMAP-210	Somatic
GOLGA5	14q32.12	RFG5, GOLIM5, ret-II	Somatic	-Colorectal Cancer -Liver Cancer -Thyroid Cancer
CHGA	14q32.12	CGA		-Liver Cancer -Lung Cancer -Lung Cancer, Non-Small Cell -Neuroblastoma -Pancreatic Cancer -Pheochromocytoma and Paraganglioma -Pituitary Tumors -Prostate Cancer -Stomach Cancer -von Hippel-Lindau Disease
SERPINA1	14q32.13	PI, A1A, AAT, PI1, A1AT, PRO2275, alpha1AT		-Cervical Cancer -Esophageal Cancer -Liver Cancer -Lung Cancer -Lung Cancer, Non-Small Cell -Pancreatic Cancer -Thyroid Cancer
DICER1	14q32.13	DCR1, MNG1, Dicer, HERNA, RMSE2, Dicer1e, K12H4.8-LIKE	Germline & Somatic	-Bladder Cancer -Eye Cancer -Lung Cancer -Small Cell Lung Cancer -Ovarian Cancer -Skin Cancer -Stomach Cancer -Testicular Cancer -Thyroid Cancer -Wilms Tumour
TCL6	14q32.13	TNG1, TNG2	Somatic	-Chronic Lymphocytic Leukemia -Leukaemia
TCL1A	14q32.13	TCL1	Somatic	-Chronic Lymphocytic Leukemia -Leukaemia
MEG3	14q32.2	GTL2, FP504, prebp1, PRO0518, PRO2160, LINC00023, NCRNA00023, onco-lncRNA-83		-Bladder Cancer -Cervical Cancer -Kidney Cancer -Liver Cancer -Lung Cancer -Pituitary Tumors
DLK1	14q32.2	DLK, FA1, ZOG, pG2, DLK-1, PREF1, Delta1, Pref-1		-Liver Cancer -Multiple Myeloma -Neuroblastoma -Pituitary Tumors
BCL11B	14q32.2	ATL1, RIT1, CTIP2, IMD49, CTIP-2, ZNF856B, ATL1-beta, ATL1-alpha, ATL1-delta, ATL1-gamma, hRIT1-alpha	Somatic	-Acute Myeloid Leukaemia -Chronic Lymphocytic Leukemia -Leukaemia -Lymphoma
WARS	14q32.2	IFI53, IFP53, GAMMA-2		-Acute Myeloid Leukaemia -Breast Cancer -Chronic Myelogenous Leukemia -Lung Cancer
MIR127	14q32.2	MIRN127, mir-127, miRNA127		-Breast Cancer -Cervical Cancer -Liver Cancer -Stomach Cancer
HSP90AA1	14q32.31	EL52, HSPN, LAP2, HSP86, HSPC1, HSPCA, Hsp89, Hsp90, LAP-2, HSP89A, HSP90A, HSP90N, Hsp103, HSPCAL1, HSPCAL4, HEL-S-65p	Somatic	-Acute Myeloid Leukaemia -Breast Cancer -Colorectal Cancer -Liver Cancer -Ovarian Cancer -Stomach Cancer
TRAF3	14q32.32	CAP1, LAP1, CAP-1, CRAF1, IIAE5, CD40bp		-Hodgkin Lymphoma -Multiple Myeloma
AKT1	14q32.33	AKT, PKB, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHA	Somatic	-Bladder Cancer -Breast Cancer -Cervical Cancer -Cowden Syndrome -Lung Cancer -Skin Cancer -Soft Tissue Sarcoma
MTA1	14q32.33			-Breast Cancer -Cervical Cancer -Stomach Cancer
IGH	14q32.33	IGD1, IGH@, IGHJ, IGHV, IGHD@, IGHJ@, IGHV@, IGH.1@, IGHDY1	Somatic Translocation	-MALT Lymphoma -Acute Lymphocytic Leukaemia (ALL) -Chronic Lymphocytic Leukemia -Lymphoma -Mantle-Cell Lymphoma -Multiple Myeloma -Non-Hodgkin Lymphoma -Waldenstrom's Macroglobulinemia
XRCC3	14q32.33	CMM6		-Breast Cancer -Colorectal Cancer -Head and Neck Cancers -Lung Cancer -Lung Cancer, Non-Small Cell -Ovarian Cancer
JAG2	14q32.33	HJ2, SER2		-Breast Cancer -Lung Cancer -Multiple Myeloma -Stomach Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 14:

Abnormality	Type	Gene(s)
add(14q32) / dup(14p32) in Non-Hodgkin's Lymphoma	Add
14q Deletions in Mesothelioma (14q11-q12 and 14q23-q24)	Deletion
14q Deletions in Neuroblastoma	Deletion
t(11;14)(q13;q32) in Myeloma	Translocation
t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt's lymphoma	Translocation
t(8;14)(q11.2;q32) in Childhood ALL (Down's associated)	Translocation
t(11;14)(q13;q32) in Mantle Cell Lymphoma	Translocation	IGH (14q32.33)	CCND1 (11q13.3)
t(14;18)(q32;q21) in Acute Lymphoblastic Leukaemia	Translocation
t(14;18)(q32;q21) in Non-Hodgkin's Lymphoma	Translocation
t(3;14)(q27;q32) in B-cell non-Hodgkin's lymphoma	Translocation
t(1;14)(q21;q32) BCL9/IGH	Translocation	IGH (14q32.33)	BCL9 (1q21.2)
t(11;14)(q23;q32) IGH-DDX6 Translocations in Hematologic Cancers	Translocation	IGH (14q32.33)	DDX6 (11q23.3)
t(1;14)(q21;q32) and MUC1 Overexpression in NHL	Translocation	IGH (14q32.33)	MUC1 (1q22)
t(6;14)(p25,q32) in Lymphomas	Translocation	IGH (14q32.33)	IRF4 (6p25.3)
t(6;14)(p25;q32) in Myeloma	Translocation	IGH (14q32.33)	IRF4 (6p25.3)
t(11;14)(p15;q11) and LMO1 in T-ALL	Translocation
t(9;14)(p13;q32) in Lymphoma	Translocation
t(1;14)(p22;q32) in MALT B cell lymphoma	Translocation

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.