ARHGEF12

Gene Summary

Gene:ARHGEF12; Rho guanine nucleotide exchange factor (GEF) 12
Aliases: LARG, PRO2792
Location:11q23.3
Summary:Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Databases:OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene
Protein:rho guanine nucleotide exchange factor 12
HPRD
Source:NCBIAccessed: 27 August, 2015

Ontology:

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Pathways:What pathways are this gene/protein implicaed in?
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