Chromosome 21
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Selected list of common recurrent structural abnormalities - Chromosome 21:
Abnormality | Type | Gene(s) | |
ERG-TMPRSS2 Fusion in Prostate Cancer | Intronic Deletion or Translocation | ERG (21q22.2) | TMPRSS2 (21q22.3) |
t(8;21)(q22;q22) in Acute Myeloid Leukemia | Translocation | RUNX1 (21q22.12) | RUNX1T1 (8q21.3) |
t(12;21) in Adult Lyphocytic Leukaemia | Translocation | RUNX1 (21q22.12) | ETV6 (12p13.2) |
t(16;21)(p11;q22) in Leukemia (ANLL) | Translocation | ERG (21q22.2) | FUS (16p11.2) |
ETV1 translocations in Prostate Cancer | Translocation | TMPRSS2 (21q22.3) | ETV1 (7p21.2) |
t(12;21) in Childhood Acute Lymphoblastic Leukaemia | Translocation | RUNX1 (21q22.12) | ETV6 (12p13.2) |
t(3;21)(q26;q22) in Secondary Leukaemia / MDS | Translocation | RUNX1 (21q22.12) | MECOM (3q26.2) |
t(21;22) EWSR1-ERG Translocations in Ewing's Sarcoma | Translocation | ERG (21q22.2) | EWSR1 (22q12.2) |
t(16;21)(p11;q22) FUS-ERG in Acute Myelogenous Leukemia | Translocation | ERG (21q22.2) | FUS (16p11.2) |
Trisomy 21 / Chromosome 21 Mutations in Childhood Leukaemia | Trisomy | ||
Trisomy 21 in Down Syndrome | Trisomy |
This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.
Atlas of Genetics and Cytogenetics in Oncology and Haematology
NCBI Genome Data Viewer
Chromosome 21 (Phenotype entries)
OMIM
Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.
Cite this page: Cotterill SJ. Chromosome 21, Cancer Genetics Web: http://www.cancer-genetics.org/clinkc21.htm Accessed:
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