Chromosome 20

Genes Linked with Cancer (57)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 20; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
FOXA2 20p11 HNF3B, TCF3B-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
-Stomach Cancer
PYGB 20p11.21 GPBB
NKX2-2 20p11.22 NKX2B, NKX2.2-Astrocytoma, Childhood
-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Ewing's Sarcoma
BMP2 20p12 BDA2, BMP2A-Bone Cancer (primary)
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Osteosarcoma
-Prostate Cancer
JAG1 20p12.1-p11.23 AGS, AHD, AWS, HJ1, CD339, JAGL1-Acute Myeloid Leukaemia
-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
PCNA 20p12.3 ATLD2Somatic-Breast Cancer
-Colorectal Cancer
-Eye Cancer
-Liver Cancer
-Lung Cancer
-Stomach Cancer
RASSF2 20p13 CENP-34, RASFADIN
Methylation
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Ovarian Cancer
-Stomach Cancer
-Thyroid Cancer
CDC25B 20p13 -Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Lung Cancer
HCK 20q11-q12 JTK9, p59Hck, p61Hck-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Kidney Cancer
-Leukaemia
-Stomach Cancer
STK4 20q11.2-q13.2 KRS2, MST1, YSK3, TIIAC-Haematological Malignancies
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
ASIP 20q11.2-q12 ASP, AGSW, AGTI, AGTIL, SHEP9-Melanoma
-Skin Cancer
-Basal Cell Carcinoma (BCC) - Skin
TPX2 20q11.2 DIL2, p100, DIL-2, HCTP4, FLS353, HCA519, REPP86, C20orf1, C20orf2, GD:C20orf1-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
GHRH 20q11.2 GRF, INN, GHRF-Breast Cancer
-Oral Cavity Cancer
-Pancreatic Cancer
-Pituitary Tumors
-Prostate Cancer
DNMT3B 20q11.2 ICF, ICF1, M.HsaIIIB-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Testicular Cancer
ASXL1 20q11.21 MDS, BOPSSomatic-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Myelodysplastic Syndromes
-Myeloproliferative Disorders
-Wilms Tumour
BCL2L1 20q11.21 BCLX, BCL2L, BCLXL, BCLXS, Bcl-X, bcl-xL, bcl-xS, PPP1R52, BCL-XL/S-Breast Cancer
-Lung Cancer
-Ovarian Cancer
E2F1 20q11.22 RBP3, E2F-1, RBAP1, RBBP3-Breast Cancer
-Liver Cancer
-Prostate Cancer
ITCH 20q11.22 AIF4, AIP4, ADMFD, NAPP1-Melanoma
-Multiple Endocrine Neoplasia
-Skin Cancer
NNAT 20q11.23 Peg5-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Colorectal Cancer
-Kidney Cancer
-Lung Cancer
-Pituitary Tumors
-Soft Tissue Sarcoma
RBL1 20q11.23 PRB1, p107, CP107-Cervical Cancer
-Retinoblastoma
SRC 20q11.23 ASV, SRC1, THC6, c-SRC, p60-Src-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Osteosarcoma
-Prostate Cancer
MAFB 20q12 KRML, MCTO, DURS3Somatic
Translocation
Overexpression
-Multiple Myeloma
TOP1 20q12 TOPISomatic
Translocation
-Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Neuroblastoma
-Soft Tissue Sarcoma
-Testicular Cancer
PTPRT 20q12-q13 RPTPrho-Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Melanoma
-Skin Cancer
NCOA3 20q12 ACTR, AIB1, RAC3, SRC3, pCIP, AIB-1, CTG26, SRC-3, CAGH16, KAT13B, TNRC14, TNRC16, TRAM-1, bHLHe42-Breast Cancer
-Prostate Cancer
SLPI 20q12 ALP, MPI, ALK1, BLPI, HUSI, WAP4, WFDC4, HUSI-I-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Ovarian Cancer
-Stomach Cancer
-Uterine Sarcoma
AURKA 20q13 AIK, ARK1, AURA, BTAK, STK6, STK7, STK15, AURORA2, PPP1R47-Bladder Cancer
-Breast Cancer
-Skin Cancer
-Stomach Cancer
-Uterine Sarcoma
CSE1L 20q13 CAS, CSE1, XPO2-Colorectal Cancer
-Liver Cancer
-Ovarian Cancer
-Skin Cancer
CYP24A1 20q13 CP24, HCAI, CYP24, P450-CC24-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
BMP7 20q13 OP-1-Bone Cancer (primary)
-Breast Cancer
-Eye Cancer
-Lung Cancer
-Melanoma
-Prostate Cancer
PTPN1 20q13.1-q13.2 PTP1B-Breast Cancer
-Esophageal Cancer
-Hodgkin Lymphoma
-Ovarian Cancer
CEBPB 20q13.1 TCF5, IL6DBP, NF-IL6, C/EBP-beta-Acute Myeloid Leukaemia
-Bladder Cancer
-Breast Cancer
-Cervical Cancer
CD40 20q13.12 p50, Bp50, CDW40, TNFRSF5-Chronic Lymphocytic Leukemia
-Kaposi Sarcoma
-Liver Cancer
-Stomach Cancer
-Thymoma and Thymic Carcinoma
SDC4 20q13.12 SYND4Somatic-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
HNF4A 20q13.12 TCF, HNF4, MODY, FRTS4, MODY1, NR2A1, TCF14, HNF4a7, HNF4a8, HNF4a9, NR2A21, HNF4alpha-Colorectal Cancer
-Liver Cancer
MMP9 20q13.12 GELB, CLG4B, MMP-9, MANDP2-Cervical Cancer
-Soft Tissue Sarcoma
-Uterine Sarcoma
SULF2 20q13.12 HSULF-2-Breast Cancer
-Liver Cancer
-Lung Cancer
-Stomach Cancer
MYBL2 20q13.12 BMYB, B-MYBOverexpression-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Neuroblastoma
-Prostate Cancer
WISP2 20q13.12 CCN5, CT58, CTGF-L-Adrenocortical Cancer
-Breast Cancer
UBE2C 20q13.12 UBCH10, dJ447F3.2-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
SALL4 20q13.2 DRRS, HSAL4, ZNF797, dJ1112F19.1-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Leukaemia
-Liver Cancer
-Ovarian Cancer
NFATC2 20q13.2 NFAT1, NFATPSomatic
Translocation
-Bone Cancer (primary)
-Breast Cancer
-Ewing's Sarcoma
-Pancreatic Cancer
ZNF217 20q13.2 ZABC1-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Stomach Cancer
BCAS1 20q13.2 AIBC1, NABC1-Breast Cancer
SNAI1 20q13.2 SNA, SNAH, SNAIL, SLUGH2, SNAIL1, dJ710H13.1-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Ovarian Cancer
-Stomach Cancer
PTK6 20q13.3 BRK-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
EEF1A2 20q13.3 HS1, STN, EF1A, STNL, EEF1AL, EF-1-alpha-2-Breast Cancer
-Ovarian Cancer
BIRC7 20q13.3 KIAP, LIVIN, MLIAP, RNF50, ML-IAP-Acute Lymphocytic Leukaemia (ALL)
-Bladder Cancer
-Eye Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Prostate Cancer
RTEL1 20q13.3 NHL, RTEL, DKCA4, DKCB5, PFBMFT3, C20orf41-Astrocytoma, Childhood
-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Melanoma
-Skin Cancer
TFAP2C 20q13.31 ERF1, TFAP2G, hAP-2g, AP2-GAMMA-Acute Myeloid Leukaemia
-Breast Cancer
-Leukaemia
-Melanoma
CTCFL 20q13.31 CT27, BORIS, CTCF-T, HMGB1L1, dJ579F20.2-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Stomach Cancer
-Testicular Cancer
-Uterine Sarcoma
GNAS 20q13.32 AHO, GSA, GSP, POH, GPSA, NESP, SCG6, SgVI, GNAS1, C20orf45Somatic-Bladder Cancer
-Pancreatic Cancer
-Prostate Cancer
-Skin Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
-Thyroid Cancer
-von Hippel-Lindau Disease
TNFRSF6B 20q13.33 M68, TR6, DCR3, M68E, DJ583P15.1.1Somatic
Amplification
Overexpression
Many cancer types including:
-Colorectal Cancer
-Esophageal Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Stomach Cancer
-Chemotherapy
SOX18 20q13.33 HLTS, HLTRS-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Uterine Sarcoma
SS18L1 20q13.33 CREST, LP2261Somatic-Synovial Sarcoma
ADRM1 20q13.33 ARM1, ARM-1, GP110-Colorectal Cancer
-Ovarian Cancer
GATA5 20q13.33 GATAS, bB379O24.1-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Kidney Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Stomach Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 20:

Abnormality Type Gene(s)
t(20;22) EWSR1-NFATC2 in Ewing's SarcomaTranslocationNFATC2 (20q13.2)EWSR1 (22q12.2)
t(11;20) (p15;q11) NUP98-TOP1 Fusion in AMLTranslocationTOP1 (20q12)NUP98 (11p15.4)
Occasional translocation of MAFB in MyelomaTranslocationMAFB (20q12)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.

Further Resources (3 links)

Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.

Cite this page: Cotterill SJ. Chromosome 20, Cancer Genetics Web: http://www.cancer-genetics.org/clinkc20.htm Accessed:

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