FAS
Gene: | FAS; Fas cell surface death receptor |
Aliases: | APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6 |
Location: | 10q23.31 |
Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011] |
Databases: | OMIM, HGNC, Ensembl, GeneCard, Gene |
Protein: | tumor necrosis factor receptor superfamily member 6 |
Source: | NCBIAccessed: 31 August, 2019 |
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Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
FAS
OMIM, Johns Hopkin University
Referenced article focusing on the relationship between phenotype and genotype.
FAS
International Cancer Genome Consortium.
Summary of gene and mutations by cancer type from ICGC
FAS
COSMIC, Sanger Institute
Somatic mutation information and related details
FAS
GEO Profiles, NCBI
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository.
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Cite this page: Cotterill SJ. TNFRSF6, Cancer Genetics Web: http://www.cancer-genetics.org/TNFRSF6.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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[Home] Page last revised: 31 August, 2019 Cancer Genetics Web, Established 1999