| PHOX2B | 4p13 | PMX2B, NBLST2, NBPhox | Germline & Somatic | -Familial Neuroblastoma
-Neuroblastoma
|
| UCHL1 | 4p13 | NDGOA, PARK5, PGP95, SPG79, PGP9.5, Uch-L1, HEL-117, PGP 9.5, HEL-S-53 | | -Cervical Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Non-Hodgkin Lymphoma
-Pancreatic Cancer
-Stomach Cancer
|
| TLR1 | 4p14 | TIL, CD281, rsc786, TIL. LPRS5 | | -Breast Cancer
-Cervical Cancer
-Multiple Myeloma
-Prostate Cancer
|
| TLR6 | 4p14 | CD286 | | -Breast Cancer
-Cervical Cancer
-Prostate Cancer
|
| RFC1 | 4p14 | A1, RFC, PO-GA, RECC1, MHCBFB, RFC140 | | -Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
|
| RHOH | 4p14 | TTF, ARHH | Somatic | -Chronic Lymphocytic Leukemia
-Non-Hodgkin Lymphoma
-Skin Cancer
|
| PCDH7 | 4p15.1 | BHPCDH, BH-Pcdh, PPP1R120 | | -Bone Cancer (primary)
-Colorectal Cancer
-Prostate Cancer
-Transitional Cell Cancer of the Renal Pelvis and Ureter
|
| SLC34A2 | 4p15.2 | NPTIIb, NAPI-3B, NAPI-IIb | Somatic
Fusion | -Kidney Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Thyroid Cancer
|
| RBPJ | 4p15.2 | SUH, csl, AOS3, CBF1, KBF2, RBP-J, RBPJK, IGKJRB, RBPSUH, IGKJRB1 | | -Colorectal Cancer
|
| PPARGC1A | 4p15.2 | LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1alpha, PGC-1(alpha) | | -Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
|
| SLIT2 | 4p15.31 | SLIL3, Slit-2 | | -Breast Cancer
-Colorectal Cancer
-Kidney Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
|
| CD38 | 4p15.32 | ADPRC1, ADPRC 1 | | -Acute Myeloid Leukaemia
-Chronic Lymphocytic Leukemia
-Lymphoma
|
| S100P | 4p16.1 | MIG9 | | -Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
|
| TACC3 | 4p16.3 | ERIC1, ERIC-1 | | -Bladder Cancer
-Brain Tumours, Childhood
-Cervical Cancer
-Lung Cancer
-Multiple Myeloma
|
| NSD2 | 4p16.3 | WHS, TRX5, KMT3F, KMT3G, MMSET, WHSC1, REIIBP | Somatic | -Mantle-Cell Lymphoma
-Multiple Myeloma
|
| CTBP1 | 4p16.3 | BARS | | -Adenomatous Polyposis Coli
-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
|
| FGFR3 | 4p16.3 | ACH, CEK2, JTK4, CD333, HSFGFR3EX | Somatic | -Bladder Cancer
-Cervical Cancer
-Lung Cancer
-Multiple Myeloma
-Skin Cancer
-Testicular Cancer
-Transitional Cell Cancer of the Renal Pelvis and Ureter
-Urinary System Cancers
|
| REST | 4q12 | WT6, XBR, NRSF | | -Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Medulloblastoma
-Neuroblastoma
-Ovarian Cancer
-Prostate Cancer
|
| CLOCK | 4q12 | KAT13D, bHLHe8 | | -Breast Cancer
-Colorectal Cancer
-Stomach Cancer
|
| IGFBP7 | 4q12 | AGM, PSF, TAF, FSTL2, IBP-7, MAC25, IGFBP-7, RAMSVPS, IGFBP-7v, IGFBPRP1 | | -Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Liver Cancer
-Melanoma
-Skin Cancer
-Stomach Cancer
|
| CHIC2 | 4q12 | BTL | Somatic | -Leukaemia
|
| KDR | 4q12 | FLK1, CD309, VEGFR, VEGFR2 | Somatic | -Breast Cancer
-Eye Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
|
| FIP1L1 | 4q12 | Rhe, FIP1, hFip1 | Somatic
Deletion / Translocation | -Leukaemia
|
| PDGFRA | 4q12 | CD140A, PDGFR2, PDGFR-2 | Somatic
Deletion / Translocation | -Cervical Cancer
-Gastrointestinal Cancers
-Gastrointestinal Stromal Tumors
-Leukaemia
-Skin Cancer
-Stomach Cancer
-Testicular Cancer
-Thyroid Cancer
|
| KIT | 4q12 | PBT, SCFR, C-Kit, CD117 | Germline & Somatic | -Acute Myeloid Leukaemia
-Bladder Cancer
-Eye Cancer
-Gastrointestinal Cancers
-Gastrointestinal Stromal Tumors
-Lung Cancer
-Melanoma
-Osteosarcoma
-Skin Cancer
-Soft Tissue Sarcoma
-Thyroid Cancer
-Uterine Sarcoma
-Vulvar Cancer
|
| EPHA5 | 4q13.1-q13.2 | EK7, CEK7, EHK1, HEK7, EHK-1, TYRO4 | | -Astrocytoma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
|
| UGT2B15 | 4q13.2 | HLUG4, UGT2B8, UDPGTH3, UDPGT 2B8, UDPGT2B15 | | -Breast Cancer
-Prostate Cancer
|
| UGT2B7 | 4q13.2 | UGT2B9, UDPGTH2, UDPGT2B7, UDPGTh-2, UDPGT 2B7, UDPGT 2B9 | | -Bladder Cancer
-Breast Cancer
-Liver Cancer
-Prostate Cancer
|
| UGT2B17 | 4q13.2 | BMND12, UDPGT2B17 | | -Bladder Cancer
-Breast Cancer
-Chronic Lymphocytic Leukemia
-Lung Cancer
-Prostate Cancer
|
| GNRHR | 4q13.2 | HH7, GRHR, LRHR, LHRHR, GNRHR1 | | -Adrenocortical Cancer
-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
-Uterine Sarcoma
|
| CXCL3 | 4q13.3 | GRO3, GROg, MIP2B, SCYB3, MIP-2b, CINC-2b | | |
| CXCL1 | 4q13.3 | FSP, GRO1, GROa, MGSA, NAP-3, SCYB1, MGSA-a | | -Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
|
| CXCL2 | 4q13.3 | GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a | | -Breast Cancer
-Colorectal Cancer
|
| CXCL5 | 4q13.3 | SCYB5, ENA-78 | | -Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
-Prostate Cancer
|
| MUC7 | 4q13.3 | MG2 | | -Bladder Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Transitional Cell Cancer of the Renal Pelvis and Ureter
|
| AREG | 4q13.3 | AR, SDGF, AREGB, CRDGF | | -Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Soft Tissue Sarcoma
|
| AFP | 4q13.3 | AFPD, FETA, HPAFP | | -Liver Cancer
|
| EREG | 4q13.3 | ER, Ep, EPR | | -Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
|
| RASSF6 | 4q13.3 | |
Methylation | -Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Neuroblastoma
|
| CXCL13 | 4q21.1 | BLC, BCA1, ANGIE, BCA-1, BLR1L, ANGIE2, SCYB13 | | -Breast Cancer
-Ovarian Cancer
-Pancreatic Cancer
|
| CCNG2 | 4q21.1 | | | -Brain Tumours, Childhood
-Breast Cancer
-Prostate Cancer
|
| CXCL9 | 4q21.1 | CMK, MIG, Humig, SCYB9, crg-10 | | -Breast Cancer
-Chronic Lymphocytic Leukemia
-Melanoma
-Skin Cancer
|
| CXCL11 | 4q21.1 | IP9, H174, IP-9, b-R1, I-TAC, SCYB11, SCYB9B | | -Acute Myeloid Leukaemia
-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Kidney Cancer
-Lung Cancer
-Melanoma
-Prostate Cancer
-Rhabdomyosarcoma
|
| CXCL10 | 4q21.1 | C7, IFI10, INP10, IP-10, crg-2, mob-1, SCYB10, gIP-10 | | -Breast Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
|
| HPSE | 4q21.23 | HPA, HPA1, HPR1, HSE1, HPSE1 | | -Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
-Pancreatic Cancer
-Stomach Cancer
|
| PTPN13 | 4q21.3 | PNP1, FAP-1, PTP1E, PTPL1, PTPLE, PTP-BL, hPTP1E, PTP-BAS | | -Breast Cancer
-Colorectal Cancer
-Lung Cancer
|
| AFF1 | 4q21.3-q22.1 | AF4, PBM1, MLLT2 | Somatic
Translocation | -Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
|
| PKD2 | 4q22.1 | PC2, PKD4, Pc-2, APKD2, TRPP2 | | |
| IBSP | 4q22.1 | BSP, BNSP, SP-II, BSP-II | | -Bone Cancer (primary)
-Breast Cancer
-Cervical Cancer
-Osteosarcoma
|
| ABCG2 | 4q22.1 | MRX, MXR, ABCP, BCRP, BMDP, MXR1, ABC15, BCRP1, CD338, GOUT1, MXR-1, CDw338, UAQTL1, EST157481 | | -Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Lung Cancer
-Oral Cavity Cancer
-Osteosarcoma
-Pancreatic Cancer
|
| SPP1 | 4q22.1 | OPN, BNSP, BSPI, ETA-1 | | -Bone Cancer (primary)
-Breast Cancer
-Eye Cancer
-Liver Cancer
-Lung Cancer
-Uterine Sarcoma
|
| ATOH1 | 4q22.2 | ATH1, HATH1, MATH-1, bHLHa14 | | -Colorectal Cancer
-Medulloblastoma
|
| BMPR1B | 4q22.3 | ALK6, AMDD, BDA2, ALK-6, BDA1D, CDw293 | | -Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Prostate Cancer
|
| RAP1GDS1 | 4q23 | GDS1, SmgGDS | Somatic | -Breast Cancer
-Leukaemia
-Lung Cancer
-Lung Cancer, Non-Small Cell
|
| ADH1B | 4q23 | ADH2, HEL-S-117 | | -Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Head and Neck Cancers
-Liver Cancer
-Stomach Cancer
|
| ADH1C | 4q23 | ADH3 | | -Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Head and Neck Cancers
-Laryngeal Cancer
-Oral Cavity Cancer
-Stomach Cancer
|
| EIF4E | 4q23 | CBP, EIF4F, AUTS19, EIF4E1, eIF-4E, EIF4EL1 | | -Breast Cancer
-Lung Cancer
-Skin Cancer
|
| TET2 | 4q24 | MDS, KIAA1546 | Somatic | -Acute Myeloid Leukaemia
-Acute Myeloid Leukaemia (AML) - childhood
-Chronic Myelogenous Leukemia
-Myelodysplastic Syndromes
-Myeloproliferative Disorders
|
| NFKB1 | 4q24 | p50, KBF1, p105, EBP-1, CVID12, NF-kB1, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B | | -Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Multiple Myeloma
|
| CASP6 | 4q25 | MCH2 | | -Brain Stem Glioma, Childhood
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Stomach Cancer
|
| PITX2 | 4q25 | RS, RGS, ARP1, Brx1, IDG2, IGDS, IHG2, PTX2, RIEG, ASGD4, IGDS2, IRID2, Otlx2, RIEG1 | | -Breast Cancer
-Cancer Screening
-Ovarian Cancer
-Prostate Cancer
-Thyroid Cancer
|
| LEF1 | 4q25 | LEF-1, TCF10, TCF7L3, TCF1ALPHA | | -Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Skin Cancer
|
| ANXA5 | 4q27 | PP4, ANX5, ENX2, RPRGL3, HEL-S-7 | | -Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
|
| IL2 | 4q27 | IL-2, TCGF, lymphokine | Somatic | -Breast Cancer
-Chronic Lymphocytic Leukemia
-Melanoma
-Ovarian Cancer
|
| IL21 | 4q27 | Za11, IL-21, CVID11 | | -Breast Cancer
-Chronic Lymphocytic Leukemia
-Multiple Myeloma
-Ovarian Cancer
|
| CCNA2 | 4q27 | CCN1, CCNA | | -Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
|
| MAD2L1 | 4q27 | MAD2, HSMAD2 | | -Bladder Cancer
-Breast Cancer
-Lung Cancer
-Stomach Cancer
-Thyroid Cancer
|
| FAT4 | 4q28.1 | FATJ, FAT-J, CDHF14, CDHR11, HKLLS2, VMLDS2, NBLA00548 | | |
| SPRY1 | 4q28.1 | hSPRY1 | | -Breast Cancer
-Liver Cancer
-Ovarian Cancer
-Prostate Cancer
|
| FGF2 | 4q28.1 | BFGF, FGFB, FGF-2, HBGF-2 | | -Breast Cancer
-Cervical Cancer
-Melanoma
-Neuroblastoma
-Ovarian Cancer
-Prostate Cancer
-Uterine Sarcoma
|
| PCDH10 | 4q28.3 | PCDH19, OL-PCDH | | -Bladder Cancer
-Cervical Cancer
-Colorectal Cancer
-Leukaemia
-Multiple Myeloma
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
-Testicular Cancer
|
| SMAD1 | 4q31.21 | BSP1, JV41, BSP-1, JV4-1, MADH1, MADR1 | | -Prostate Cancer
|
| HHIP | 4q31.21 | HIP | | -Colorectal Cancer
-Esophageal Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Stomach Cancer
|
| IL15 | 4q31.21 | IL-15 | | -Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Lung Cancer
-Skin Cancer
|
| GAB1 | 4q31.21 | | | -Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
|
| NR3C2 | 4q31.23 | MR, MCR, MLR, NR3C2VIT | | -Acute Lymphocytic Leukaemia (ALL)
-Adrenocortical Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
|
| SFRP2 | 4q31.3 | FRP-2, SARP1, SDF-5 | | -Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Stomach Cancer
|
| TLR2 | 4q31.3 | TIL4, CD282 | | -Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Prostate Cancer
-Stomach Cancer
|
| FBXW7 | 4q31.3 | AGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10 | Somatic | -Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
-Breast Cancer
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Wilms Tumour
|
| ADAM29 | 4q34.1 | CT73, svph1 | Somatic | -Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Esophageal Cancer
|
| HPGD | 4q34.1 | PGDH, PGDH1, PHOAR1, 15-PGDH, SDR36C1 | | -Breast Cancer
-Colorectal Cancer
-Prostate Cancer
|
| VEGFC | 4q34.3 | VRP, Flt4-L, LMPH1D | | -Bladder Cancer
-Breast Cancer
-Lung Cancer
-Neuroblastoma
-Prostate Cancer
-Stomach Cancer
|
| TLR3 | 4q35.1 | CD283, IIAE2 | | -Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Melanoma
|
| ING2 | 4q35.1 | ING1L, p33ING2 | | -Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Skin Cancer
|
| CASP3 | 4q35.1 | CPP32, SCA-1, CPP32B | | -Bladder Cancer
-Lung Cancer
-Osteosarcoma
-Stomach Cancer
|
| IRF2 | 4q35.1 | IRF-2 | | -Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Esophageal Cancer
-Liver Cancer
|
| DUX4L1 | 4q35.2 | DUX4, DUX10 | Somatic | -Ewing's Sarcoma
-Rhabdomyosarcoma
-Soft Tissue Sarcoma
|
| FAT1 | 4q35.2 | FAT, ME5, CDHF7, CDHR8, hFat1 | | -Brain and CNS Tumours
-Colorectal Cancer
-Esophageal Cancer
-Head and Neck Cancers
-Oral Cavity Cancer
|
Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 4; or Sort by clicking on a column heading e.g. 'Gene'.
Chromosome 4 (Phenotype entries)